Promotion of accelerated healing in a mouse wound model with a viral immunomodulator Serp-1/chitosan gel

摘要

A unique anti-inflammatory serpin, Serp-1, has been extensively tested as a systemic therapy in animal models of inflammation and a small human clinical trial. Serp-1 has not been tested as a topical treatment for wound healing. Serp-1 has a short half-life when given intravenously and we postulated that slow release of Serp-1 is necessary to maximize the activity. This current study demonstrates that Serp-1 applied to wounds in a mouse model can significantly promote accelerated wound healing when given in a hydrogel or saline. In ongoing work, we are exploring the molecular mechanism of action.