The Role of ECM Composition in Bioengineered Lung Barrier Formation

摘要

The combination of dECM and laminin promotes optimal attachment and barrier maturation, both playing integral parts in recellularization process. The dECM coating reintroduces the ECM proteins that lost during the decellularization process, increasing initial cell attachment and driving barrier formation in the alveoli. Implementing this treatment into the standard ex vivo recellularization protocol can direct epithelial phenotype to improve bioengineered lung functionality.