Optimization of PLGA Nanoparticles for Encapsulation of Enzyme for Elimination of Bacterial Biofilms

摘要

The enzyme immobilized into PLGA NPs exhibited extended catalytic activity, engendering promise as an adjunctive anti-biofilm treatment therapy. The depletion of pyruvate can induce P. aeruginosa biofilm dispersal and the reversion of biofilm bacteria to the antibiotic-susceptible planktonic mode of growth.