Bovine ovary-derived extracellular matrix hydrogel supports in vitro growth of bovine early antral follicles

摘要

Our work demonstrates that bovine ovarian follicles can be successfully cultured in ovary-derived dECM hydrogels. Future work will investigate the tissue-and compartment- (e.g. medulla vs. cortex) specific bioactivity of dECM hydrogels. For example, we are investigating whether outcomes differ between follicles cultured in ovary-derived dECM hydrogels compared to those derived from testis- or other non-matched tissue dECM hydrogels. This study contributes to a body of work regarding biomaterials for follicle culture and transplantation, with the ultimate goal of developing functional ovarian tissue mimics.