Spatially Organized 3D-Printed Scaffolds for Osteochondral Interface Regeneration

摘要

This work demonstrates a tunable platform to control multi-peptide organization within a continuous 3D-printed construct. Bioactive peptides designed for OC tissue engineering influenced hMSC chondrogenesis and osteogenesis. Notably, the presence of both peptides in a single scaffold resulted in a synergistic effect that further enhanced cellular responses. Ongoing and future work includes varying print patterns to evaluate the added effect of scaffold porosity on hMSC behavior. Biochemical and physical cues can therefore be optimized independently to synergistically guide local cell behavior and spatial tissue formation.