Scaffold-free self-organized 3D artificial tissue and bone composite for osteochondral regeneration

摘要

An improved treatment method for osteochondral injury is provided. A composite tissue comprising a three-dimensional artificial tissue and an artificial bone for treating or preventing a disease, disorder or condition associated with osteochondral defect, the three-dimensional artificial tissue substantially comprising: It is composed of cells and an extracellular matrix derived from the cells, and the extracellular matrix contains fibronectin, collagen I, collagen III and vitronectin, and the extracellular matrix is dispersed and arranged in the tissue. Complex organization.