On a Novel, Simplified Model Framework Describing Ascorbic Acid Concentration Dynamics

摘要

Ascorbic acid is an essential aminoacid which interacts in several parts of the human body metabolism. The ascorbic acid concentration is controlled by homeostasis, a biological, autonomous control function in the body. Humans are not able to produce ascorbic acid, and the ascorbic acid concentration is maintained by daily oral digestion. Ascorbic acid is buffered in various tissues, such as the adrenal glands, brain, muscles, and other. Excessive ascorbic acid is extracted from the body through urine and intestines. Measuring ascorbic acid concentration in the body is challenging, and special procedures must be followed when extracting a blood sample and performing a concentration analysis. This paper presents a novel, simplified model framework of the ascorbic acid homeostasis in the human body plasma and tissues, including tissues such as adrenal glands, brain, liver, muscles and bone marrow. These tissues also act as ascorbic acid concentration buffers, in case of low oral supply. The dynamic model framework is based on mass balances of ascorbate acid in various tissues, including tissue buffer terms involving the intestine, kidney, adrenal glands, and other critical and noncritical tissues. The interaction between buffer tissues and fluids is maintained by the body homeostasis using chemical transport protein molecules. Additional usage terms describing energy metabolism, body growth, and immune system response are also included. This dynamic model framework, including the ascorbic acid concentration control system, is simulated with assumed parameters based on available literature. The results indicates that further investigations using experiments, in addition to adaptive model parameter estimation schemes and additional model verification tests are needed in order to identify the various model framework parameters to fit the human body ascorbic acid homeostasis and pharmacokinetics.