Design of Multi-Channel Monopolar Biphasic Stimulator for Implantable Biomedical Applications

摘要

Neuro-stimulators have been widely used in neural disorder control. This work presents a four-channel stimulator with adjustable positive and negative stimulus voltage from ±0.5V to ±8V. In the proposed stimulator, circuit operation with negative voltage has been successfully realized in a 0.25-μm 2.5V/5-V/12-V CMOS process with the grounded p-type substrate, and without suffering the p-n junction breakdown or electrical overstress issues. The proposed stimulator has been also practically verified with in-vivo animal test. By integrating the stimulator circuit with other circuit blocks together, the close-loop neuromodulation treatment can be implemented by an implantable system-on-chip (SoC) with low-power consumption.