Hydrophobic Core, pH-responsive ABC Triblock Copolymers for Formulation of Stabilized siRNA Polyplexes

摘要

The use of a triblock architecture with a PPS hydrophobic block improved the stability properties of the polymers and enabled higher luciferase model gene knockdown in breast cancer cells. This improved stability may lead to longer circulation times in vivo and an overall more efficient si-NP drug delivery system.