In this study, we successfully prepare porous collagen based sponges for use in hemostatic applications. Among the fabricated sponges, DFC/silk sponge possessed the structural characteristics of larger interconnected pores than all others sponge. The incorporation of SF significantly increased the DFC sponge's porosity but did not alter the water uptake capacity. The results of the whole blood clotting experiment indicated that the DFC/silk sponge had a better clotting ability to that of avitene in vitro. Rat femoral artery hemorrhage experiment showed the similar hemostatic ability of DFC-based sponges to avetine. The comparable hemostatic potential to the commercial hemostatic agent avitene confirms the possibility of the DFC-based sponges to be utilized as a hemostatic agent.
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