Lanthanides-Doped Upconversion and Downconversion Hydroxyapatite Nanoparticles for Biomedical Tracking

摘要

These uniform downconversion HA nanoparticles were demonstrated to be dominant in cell imaging. The upconversion HA nanoparticles showed advantage in tracking the material-tissue distribution, revealing the osteointegration, as well as avoiding the tissue autofluorescence. These lanthanides-doped HA nanoparticles with a long-term stable fluorescence are fit for imaging cells and tracking bone reconstruction, and will exhibit their versatility in future biomedical applications.