Thixotropic Hydrogels of PEGylated Dendrimer and Alpha-Cyclodextrin for Gene and Drug Delivery

摘要

α-CD/PG5-based thixotropic supramolecular hydrogels were successfully formed at different α-CD/PEG ratios and after loading with siRNA as a model therapeutic. This success was confirmed by showing the invertibility of the hydrogels after their incubation period as well as by rheology. Work is currently ongoing to test and compare how different α-CD/PEG ratios effect the mechanical properties of each hydrogel. The ability to load different therapeutics such as anti-cancer drugs are also being pursued.