Understanding Systemic Immune Dysregulation in Severe Trauma and the Effects of Biomaterial-based Interventions

摘要

Complications in bone defect healing, especially in immune dysregulated patients, remains a significant clinical challenge. Our preliminary results show strong evidence of immune dysregulation and suppression at 8 weeks post-injury in our clinically-relevant rat model. Even with treatment at week 8 using two different biomaterial-mediated BMP-2 delivery strategies, immune dysregulation persisted, and possibly even worsened. Despite this, radiographs showed evidence of early mineralization, but this could be attributed to the high dosage of BMP-2 used. Further detailed analyses will provide a more complete interpretation of the links between bone healing, biomaterial delivery strategies, and the immune system status. Understanding the immune response to biomaterial-mediated treatment strategies in the context of immune dysregulation will guide improvements in future therapeutics.