Anti-Biofilm Efficacy of Nitric Oxide-Releasing Alginates against Respiratory Pathogens

摘要

The bactericidal action ot NO-releasing alginate materials was clearly demonstrated against P. aeruginosa biofilms. The antibiofilm efficacy was dependent on the identity of the secondary amine functional group due to its influence on the NO payload and associated NO-release kinetics. Experiments are underway to evaluate the anti-biofilm efficacy NO-releasing alginates against Staphylococcus aureus, methicillin resistant S. aureus, and Burkholderia cepacia. This research was supported by the National Institutes of Health (AI 112029) and Know BIO, LLC.