3D Printing Spatially Organized Scaffolds for Osteochondral Interface Regeneration

摘要

This work demonstrates a tunable platform to control peptide concentration, peptide organization, and scaffold architecture within a continuous 3D-printed biomaterial to guide OC interface tissue organization. Biochemical and biophysical organization can be easily modified, thereby introducing strategies to optimize local cell behavior and spatial tissue formation. Currently, we are investigating hMSC differentiation profiles and matrix formation in scaffolds with different porosities and single-and dual-peptide functionalization.