Low-noise Transimpedance Amplifier Design using Chopper-stabilized Technique for Nanopore Applications

摘要

This paper presents a low-noise transimpedance amplifier (TIA) employing chopper-stabilized technique for nanopore applications. The TIA, which is used as a headstage for the monitoring system, must achieve low-noise performance to accurately measure a minute ionic current signal generated from the nanopore. In this work, we analyze detailed input-referred noise current of the capacitive-feedback TIA and propose a core amplifier adopting the chopper-stabilized technique to effectively reduce flicker noise in a bandwidth of interest for nanopore applications. This proposed circuit schematic is designed by harnessing 0.35 μm CMOS process and is verified using elaborate simulation results.