Implantable IoT System for Closed-Loop Epilepsy Control based on Electrical Neuromodulation

摘要

A closed-loop system aiming at epilepsy control is proposed in this paper, in which electrical stimulation is triggered upon a decision aggragating different biological signatures of the seizure such as changes in the heart rate, blood flow in the brain, along side the changes in the iEEG signals. iEEG signals are recorded and processed in the implantable part of the system. Electrical stimulation of deep-brain or vagus nerve targets which are known to be effective in seizure abortion is started upon detection of a seizre onset. This paper focuses on the implantable part of the system including a high dynamic-range amplifier, a sub-ranging/amplification stage, a line-length feature extractor and a stimulator. The implantable part is integrated using a 0.18 μm technology.