Computational Study of Hodgkin-Huxley Type Calcium-Dependent Potassium Current in Urinary Bladder Over Activity

摘要

Detrusor smooth muscle (DSM) instability is a common symptom of over active bladder (OAB) which effects quality of millions of lives. The enhanced spontaneous contraction due to generation of more frequent spontaneous action potentials (AP) is the fundamental cause of DSM instability. Ca²⁺ dependent potassium channels are abundantly distributed in DSM cells and regulate the membrane excitability by modulating AP shape and the resting membrane potential. Quantitative studies of these channels will help to predict the underlying mechanism of electrical signaling in DSM cells. Here, we present a large conductance Ca²⁺ dependent potassium (BK) channel based upon Hodgkin-Huxley (HH) formalism which is incorporated into a published single DSM cell model to investigate several modulating effects. This simple BK ion channel model is constructed with biophysical details from documented electrophysiological studies. As it reflects several modulating properties found in DSM cell electrophysiology, further investigation can shed light in genesis of OB.