Proliferation of fibroblast on pore size controlled three-dimensional scaffolds by three-dimensional bioprinting

摘要

Conclusions: Highly porous and interconnected 3D gelatin scaffolds were fabricated using a 3D biopriting, coupled with a cryogenic system. The scaffold pore size was readily controlled by tailoring process parameters and the gelatin scaffold remained extremely porous. After 7 days of cell culture, HDFs proliferation rate on 3D scaffolds with the range of 800 to 1,200 μm pore sizes was faster than that on the scaffold with 600 urn. These results suggest that the pore size is important parameter in fabrication of 3D scaffold.