Chondrogenic-Inductive Nanofibrous Substrates Biofunctionalized with Immobilized Autologous TGF-β3 and IGF-I

摘要

Conclusions: The biological results indicate that the functionalized nanofibrous substrates are able to promote chondrogenesis, being more effective than the standard differentiation condition. We hypothesize that our substrates maximize the exposure of the hBMSCs to the immobilized GFs, by the close contact established between them at the surface of the substrate. The proposed biofunctional nanofibrous systems can act as an effective cartilage tissue engineering scaffold, operating as a synthetic and active ECM-like support for stimulating hBMSC growth and differentiation.