Single Cell Migration Speed on Nanofibers is Rho/ROCK and Focal Adhesion Structure Dependent

摘要

Conclusions: The focal adhesion is a complex concentration of signaling molecules that supports force during attachment and migration to a substrate. While the size of focal adhesions does not correlate well with the observed migration velocity trends, the FAK activation state and recent data on the tension experienced by vinculin offer greater support for the velocity phenotype. Future experiments will build on the scaffold properties explored to provide more insight into the scaffold design on migration potential within tissue engineered constructs.