Modulation of Cellular Response Using Mechanically Dynamic PDMS Substrates

摘要

Conclusions: We present an orthogonal crosslinking strategy to fabricate mechanically dynamic PDMS substrates, where the viscoelasticity and stiffness of the PDMS substrates can be temporal and spatial controlled using light. These photoresponsive PDMS substrates are cytocompatible and can be applied to regulate the cell morphology, showing a strong correlation between substrate stiffness and cell spreading and elongation. These results demonstrate the photoresponsive PDMS substrates provides a promising platform to study cell-matrix interactions in a dynamic manner.