Assessment of health effects of particulate pollution among traffic police in Kathmandu, Nepal using biomarkers

摘要

Serum samples collected from traffic police working on roads from six locations in Kathmandu, Nepal were analyzed for biomarkers such as CRP, SAA, ICAM-1, VCAM-1, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, and TNF-α. 81 serum samples were collected from 33 traffic police during the more polluted spring season (February 17 to April 4, 2014) and 62 serum samples were collected from 32 traffic police during relatively cleaner summer-monsoon season (July 20 to August 22, 2014). Samples were analyzed using proinflammatory panel 1 (human) kits and vascular injury 2 panel 2 (human) kits (MSD Multi-Spot Assay System, Meso Scale Discovery, MD, USA). Personal exposure levels of PM2.5, black carbon, and chemical composition of PM_(2.5) were also analyzed. PM_(2.5) exposure levels were higher in spring season than in monsoon season. The effects of exposure seem to be more pronounced among women because several biomarkers such as IFN-γ, IL-2, IL-6, IL-10, IL-12, and IL-13 were found to have the highest mean level at the site with all female traffic police though this site did not have the highest PM_(2.5) exposure levels. Association of biomarker levels with particulate pollution and several social variables will be presented.