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Development of a μCT-based Patient-Specific Model of the Electrically Stimulated Cochlea

机译:基于μCT的电刺激耳蜗患者专用模型的开发

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Cochlear implants (CIs) are neural prosthetics that are used to treat sensory-based hearing loss. There are over 320,000 recipients worldwide. After implantation, each CI recipient goes through a sequence of programming sessions where audiologists determine several CI processor settings to attempt to optimize hearing outcomes. However, this process is difficult because there are no objective measures available to indicate what setting changes will lead to better hearing outcomes. It has been shown that a simplified model of electrically induced neural activation patterns within the cochlea can be created using patient CT images, and that audiologists can use this information to determine settings that lead to better hearing performance. A more comprehensive physics-based patient-specific model of neural activation has the potential to lead to even greater improvement in outcomes. In this paper, we propose a method to create such customized electro-anatomical models of the electrically stimulated cochlea. We compare the accuracy of our patient-specific models to the accuracy of generic models. Our results show that the patient-specific models are on average more accurate them the generic models, which motivates the use of a patient-specific modeling approach for cochlear implant patients.
机译:耳蜗植入物(CIs)是一种神经假体,用于治疗基于感觉的听力损失。全球有超过320,000名收件人。植入后,每个CI接收者都要进行一系列编程会话,在此期间,听力学家确定几种CI处理器设置,以尝试优化听力结果。但是,此过程很困难,因为没有客观的指标可用来指示哪些设置更改将导致更好的听力结果。已经表明,可以使用患者的CT图像创建耳蜗内电诱发的神经激活模式的简化模型,并且听力学家可以使用此信息来确定可改善听力性能的设置。基于物理学的,基于物理学的更全面的患者特定神经激活模型有可能带来更大的治疗效果。在本文中,我们提出了一种方法来创建这种电刺激的耳蜗的定制的电解剖模型。我们将患者特定模型的准确性与通用模型的准确性进行比较。我们的结果表明,特定于患者的模型比通用模型更准确,这激发了针对人工耳蜗患者使用特定于患者的建模方法的动机。

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