Hydrogen bonding networks in transient state of beta-lactamase protein analogous to integrated circuits

摘要

Two hydrogen bonding networks (HBN) that are extracted from the β-lactamase protein are presented and studied in the present paper. The HBNs are formed in the active site of ß-lactamase when β-lactamase is in transient state (T1). The hydrogen bonds are modeled as three or four-terminal block elements analogous to classic electrical multi-terminal networks. Each block element is coded in Matlab and described by polynomials. Block elements are then included in a microelectronic circuits analogous to “proton networks”. The dynamic and static simulations with analogous circuits are carried out in Matlab. The results showed an analogy to a current source, amplifier, current mirror, and amplitude limiter.