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Muscle-actuated bio-hybrid mems by cell culture and differentiation on me tamaterial micro-scaffolds

机译:在材料微支架上通过细胞培养和分化来激活肌肉驱动的生物杂交记忆

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This paper reports on a 3D bio-hybrid metamaterial MEMS scaffold for the culture and differentiation of C2C12 muscle precursor cells. For the first time, preferential cells differentiation on a technical surface into functional myotubes is demonstrated. The micro-scaffolds are based on concatenated bowtie elements fabricated by two-photon lithography and designed to achieve an equivalent Young's modulus of 12kPa. The high flexibility promotes the differentiation of the muscle cells into contractile myotubes [1]. Compared to state-of-the-art gel-based cell culture substrates, mechanical metamaterials can be shaped into arbitrary complex 3D geometries opening pathways towards muscle-driven biohybrid MEMS.
机译:本文报道了用于C2C12肌肉前体细胞的培养和分化的3D生物杂交超材料MEMS支架。首次展示了技术表面优先分化为功能性肌管的细胞。微型支架基于通过双光子光刻技术制造的串联领结元素,并设计为达到12kPa的等效杨氏模量。高柔韧性促进了肌肉细胞向收缩性肌管的分化[1]。与基于凝胶的最新细胞培养基质相比,机械超材料可以成型为任意复杂的3D几何形状,从而为通向肌肉驱动的生物混合MEMS开辟了道路。

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