Microelectronic circuit emulating Hydrogen Bonding Network of Green Fluorescent Protein

摘要

Hydrogen Bonding Network in active site of wild type Green Fluorescent Protein during the A→A* state is modeled. A microelectronic equivalent circuit is developed on its basis to emulate the operational principle of the Hydrogen Bonding Network. It is coded in Matlab to investigate its static and dynamic behavior. Output characteristics of static analysis are similar to inversed tunnel diode. The dynamic analysis show that the circuit can operate as amplifier, modulator and amplitude limiter.