Nanoprobe biomaterials for breast cancer imaging and therapeutic visualization

摘要

Nanoprobe biomaterials are crucial to the cancer imaging daignosis and therapy. Some nanoparticulate materials are good candidates as shuttles of drug delivery and contrast agents in different biomedical imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), ultrasound tomography, positron emission tomography (PET), and optical imaging based on their special properties in magnetism, acoustics, optics, and electrics etc. Here Gd_2O_3, Fe_3O_4, or TiO_2, Au, NaYF_4:Yb/Tm, SiO_2 nanoparticle materials and their composites are employed as shuttles of drug delivery and/or contrast agents in MRI and optical therapeutic agents for cancer. In this presentation, according to our new progress, we will show that nanoparticles could act as imaging agents and therapeutic agents for cancer cells, or overcome multidrug resistance in human breast cancer cells, or target to cancer and decrease the cytotoxicity along with biomedical imaging. In future, we might use these nanoparticle materials not only localize the cancer/diseases area acting as contrast agents in biomedical imaging, but also target and treat the cancer/diseases acting as therapeutic agents simultaneously.