THE TISSUE IMPLANT RESPONSE SURROUNDING SUBCUTANEOUS TCP, HA, AND ALCAP BIOCERAMICS

摘要

The objective of this investigation was to quantify and further elucidate the tissue-implant response in the fibrous tissuesurrounding tricalcium phosphate (TCP), hydroxyapatite (HA), and aluminum calcium phosphate (ALCAP) implants whenimplanted subcutaneously. Sixteen animals in four experimental groups (n = 4/group) were implanted with one implant each:Group Ⅰ (control, TCP), Group Ⅱ (HA), and Group Ⅲ (ALCAP). At 90 days post-implantation, the fibrous tissue surroundingthe implants was harvested. Sections of stained fibrous tissue were evaluated for the presence of macrophages, fibrocytes,neutrophils, vascularity and thickness for all three groups using semi-automated quantitative methods. The analysis indicatedGroup Ⅲ demonstrated a significantly higher number of neutrophils but fewer macrophages and blood vessels per highpower field and had a substantially thinner fibrous tissue capsule thickness compared to Groups Ⅰ and Ⅱ (alpha=0.05). GroupⅡ elicited a greater response of fibroblasts compared to Groups Ⅰ and Ⅲ suggesting HA may provide a slightly higher degreeof stability to the implant. In total, these findings suggest both TCP and HA behave similarly in vivo when compared toALCAP and may be better choices for subcutaneous soft-tissue application compared to ALCAP.