These preliminary results indicate that COMPOSIX™ EX meshes are stiffer after relatively short duration of exposure to the physiological environment. Previous studies have noted similar stiffening after in vivo function. Costello found between a 4 and 30 fold decrease in the compliance of explanted meshes. The underlying cause of such increased stiffness and its relationship with clinical symptoms remains to be determined. Testing of the remaining samples in the registry of explanted surgical mesh, including both COMPOSIX™ EX and other brands, is ongoing.
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