Incorporation of Protein-based Therapeutic Agents into Coaxial Electrosprayed Particles for Cardiac Regeneration

摘要

The developed technique of coaxial electrospraying was successfully employed to incorporate protein structures into the core-shell particles. The material and processing variables, effective on encapsulation and release of SDF-1α were identified. Prolonged release of SDF-1α was obtained for 40 days, which might be long enough to elicit considerable regeneration, induced by recruited stem cells into the infarcted myocardium. More importantly, released SDF-1α from the particles could drastically stimulate migration of stem cells, which is an indication of the capability of the process to preserve the bioactivity of SDF-1α . due to very limited contact of organic phase with aqueous SDF-1α solution during the process.