Human plasma based composite muscle ECM directs adipose derived stem cells to vasculogenic and myogenic lineage

摘要

We describe a regenerative medicine approach of cell therapy for the repair of VML injuries. Here we demonstrate that the ASCs delivered via a PEGylated plasma onto decellularized muscle ECM scaffold differentiates into vasculogenic and myogenic lineages. This indicates that the composite scaffold may enhance cell migration, re-vascularize the injured muscle, and possibly promote muscle formation. Future studies are planned at investigating this hypothesis in a rodent VML injury model.