Synthesis of Protein-polymer Conjugates with Controllable Properties

摘要

In summary', our results provide a general approach for efficient on-demand control of protein property based on site-specific conjugation of polymers. Conjugation of pHEMA to the specific site on protein surface resulted in a clear and reversible decrease of protein activity. In addition, by the fast visible light assisted RAFT polymerization of NIPAm from the protein surface, protein activity is retained and in certain cases provides a conjugate with on-off-switchable properties.