Bacteriophage Encapsulation in Poly(Ethylene Glycol) Hydrogels Significantly Reduces Bacteria Numbers in an Implant-Associated Infection Model of Bone Repair

摘要

We demonstrate bacteriophage can be encapsulated into PEG hydrogels without inhibiting bactericidal ability. The presence of bacteriophage does not alter the differentiation potential of hMSCs suggesting they do not disrupt bone formation. Bacteriophage delivery significantly reduces viable bacteria in a chronic implant infection model, providing proof of concept for their feasibility as an antimicrobial strategy. Further investigation is required to assess the biocompatibility of bacteriophage, as well as the immune response and effects on bone formation of bacteriophage delivery.