Synthesis of Large Pore Sized Mesoporous Silica Nanoparticles Embedded with Magnetic Nanoparticles for Loading of Large Sized Molecules

摘要

We prepared large pore-sized MSNs embedded with magnetic nanoparticles by using co-solvent in sol-gel method. The large pore sized MSNs had large surface area, pore volume and bimodal pore structure. The surface of large pore sized MSNs were modified with amine group by silane chemistry for efficient loading of model protein and DNA. resulting in significantly enhanced adsorption than small pore sized MSNs. The large pore sized MSNs might have a potential for large molecules delivery vehicles for antigens, growth factors, and enzymes.