We propose a simple and fast method for microscopy image enhancement and quantitatively evaluate its performance on a database containing cell images obtained from microscope setups of several levels of quality. The method utilizes an efficiently and accurately estimated relative modulation transfer function to generate images of higher quality, starting from those of lower quality, by filtering in the Fourier domain. We evaluate the method visually and based on correlation coefficient and normalized mutual information. We conclude that enhanced images exhibit high similarity, both visually and in terms of information content, with acquired high quality images. This is an important result for the development of a cost-effective screening system for cervical cancer.
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