Noninvasive blood glucose detection using near infrared sensor

摘要

The development of noninvasive blood glucose detector is desired to replace invasive method which is costly and uncomfortable. Near Infrared (NIR) spectroscopy is used to detect blood glucose noninvasively since glucose has specific absorbance spectrum in NIR range, 850nm-2500nm. LED is utilized as incoherent infrared source to irradiate body surface in wavelength 1550 nm. Penetrated light is then detected by InGaAs photodiode, sensitive for wavelength 850-1700 nm. As the measurement sites, earlobe is chosen since it is thin. Photodiode's current is converted into voltage using transimpedance amplifier circuit. In order to minimize high frequency noise, low pass filter is applied consecutively. Early testing is conducted by measuring penetrated light in various concentration of glucose solution with wavelength 1300nm, 1450nm, and 1550nm. Measurement indicates correlation between voltage and glucose concentration. In earlobe testing, light can penetrate tissue with detected voltage, 300mV-4V depend on the wavelength. Linear approximation and two point equation is applied to the data. This two approach extracts formula that can estimate blood glucose concentration with maximum 30% error. By using two point equation, a specific formula for each person can be obtained.