Molecular Docking and Biological Evaluation of Functionalized benzohquinolines as Colon Cancer Agents

摘要

As a part of our drug discovery program, we have synthesized various 2-amino-benzo[h]quinoline-6-carbonitrile derivatives and analyzed them on human colon cancer cells in the form of percentage inhibition at different concentration gradient and time of incubation. Anticancer activity of these derivatives against the human HCT116 cancer cells using in vitro employing standard MTT assay. Compounds 3a-3e showed significant anti-cancer activity especially compound 3b and 3d exhibit the good inhibitory activity on HCT116 cells. Additionally, docking study was performed on colon cancer target cyclin-dependent kinase-2 to understand the cytotoxic mechanism of action of active compounds.