A New Method for Identification Potential SNP Relating to Trait on Highly Polymorphic Gene Sequence Combination NCBI Database and Multi-Sequence Alignment Software

摘要

The traditional methods for identification potential SNP related to trait on highly polymorphic gene sequence needs complex SNP statistic and analytical procedure with the premise that positive data and negative data all fulfill, but sometime we only get a small quantity sequence data of positive trait individuals for time, difficulty or other causes and may be unable to get complete negative trait individual sample data in time, can we speculate potential SNP loci beforehand? This paper shows us new method to solve this problem in the genetic epidemic disease research of psoriasis vulgaris by combination the SNP database in NCBI and multi-sequence alignment. Through the application of this method to the analysis of positive sequence of HLA-C genes, found 31 potential SNP loci that NCBI records relates to the disease in total.