Design of a Polyanhydride-Releasing Oral MicroParticle Technology (PROMPT) for Oral Vaccine Delivery

摘要

In this study, P(MAA-g-EG) hydrogels were adapted to incorporate a biodegradable crosslinker and optimized for delivery of nanoparticles. Degradation studies indicate therapeutic release at physiologically relevant pH, with tunable rate by varying crosslinking density. These studies indicate PROMPT has potential as an adaptable platform for oral vaccine administration.