Fabrication of Novel Cellulosic-Based Scaffolds for Articular Cartilage Tissue Engineering by Unidirectional Freeze Drying Method

摘要

Pure BC and BC-Chitosan scaffolds were prepared by a unidirectional freeze drying method. All the scaffolds show an alignment of the fibrils along the freezing direction with 3D interconnected porous structure which is beneficial for TE scaffolds. From the XRD results, the crystallinity index tends to decrease with increased chitosan concentration. In this way, the scaffold morphology such as pore size, distance between channels, and crystallinity can be controlled by carefully adjusting the chitosan concentration for cartilage tissue engineering.