Hydroxyapatite/poly(lactide-co-glycolide) micro-patterning on magnesium for biomedical applications

摘要

The micro-pattemed HA/PLGA was successfully produced on photo-lithographically designed Mg surface by the treatment in Ca/P aqueous solution and PLGA spin coating process. The HA pattern covered the surface periodically and PLGA filled the rest densely. Corrosion resistance of the samples was highly improved compared to the bare Mg, resulting in the decrease of degradation mass in PBS. The SEM observations revealed that the patterned layer had better stability during deformation. In conclusion, HA/PLGA micro-patterning on Mg is a promising approach to reduce the corrosion rate of Ms and improve the coating flexibility.