Preparation and characterization of in situ forming hybrid hydrogels composed of gelatin and poly(ethylene glycol)

摘要

This study describes in situ forming GHPA/GPT hybrid hydrogels prepared by a HRP-catalyzed crosslinking reaction. By varying mixing ratios of GHPA and GPT, various properties of the hybrid hydrogels could be controlled. In particular, it was found that the total content of PEG in the hybrid hydrogel system affect significantly hydrogel properties. The obtained results demonstrated that our in situ forming gelatin-based hybrid hydrogels with tunable properties and good biocompatibility hold great promise as a versatile scaffold for tissue engineering applications.