Autologusly Enriched Human Bone Marrow Aspirate for Bone Tissue Engineering

摘要

Autologous bone marrow aspirate is a great source of progenitor cell population is a great cell source for bone regeneration. The challenge arises from the use of large volumes of BMA in order to obtain enough osteo-progenitor cells which become inefficient method for bone regeneration. Here, we demonstrated the feasibility of concentrating BMA using a rapid, bedside, fully automated system and its subsequent direct differentiation into osteoblasts. Also in this study, we demonstrated the feasibility of bone formation of cBMA onto mechanically stable and porous scaffolds. The use of cBMA could lead to the development of intra-operative and clinically applicable tissue engineering strategies for segmental bone regeneration.