Targeting Astrocyte Phenotypic Switch after Neural Injury

摘要

In summary, phage biopanning assays were modified to conduct screens against a complex adherent viable cell target. We identified and characterized scFvs that (1) distinguish viable unfixed astrocytes over other cell types and (2) preferential affinity to reactive astrocytes over basal astrocytes. Such targeting motifs will be critical in developing future diagnostic and therapeutic strategies for neural injury that are sensitive to the injury microenvironment.