In vitro and in vivo assessments of pure Zn and Zn-lMg alloy as biodegradable metals

摘要

Zn-1Mg alloy shows much higher tensile strength and hardness compared with pure Zn, mainly due to grain refinement and second phase formation. The in vitro cell experiment indicated that Zn-Mg alloy exhibited better cytocompatibility and increased ALP activity than pure Zn. The in vivo results showed that the degrading rate of Zn-1Mg alloy is slow and still remain structure integrity after 2 months' implantation. The Zn-1Mg alloy can promote bone mineralization and peri-implant new bone formation without inducing any significant adverse effects. Therefore, the Zn-1Mg alloy is one of the promising degradable biomaterials for clinical application.