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Shear-Thinning Hydrogels with Secondary Michael-type Crosslinking to Modulate Properties In Situ

机译:具有次要Michael型交联的剪切稀化水凝胶可原位调节性能

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Results demonstrate the ability of the materials developed to form a shear-thinning hydrogel upon mixing, flow for injection delivery, and recover at the target site. Furthermore, biophysical properties of the injected hydrogel are controllable through the incorporation of secondary covalent crosslinking which is tailored to proceed at a clinically relevant time-scale. Ongoing work includes examination of hydrogel degradation in vivo, as well as implementing towards specific biomedical applications.
机译:结果表明,所开发的材料具有在混合时形成剪切稀化水凝胶的能力,用于注射的流动性以及在目标部位处恢复的能力。此外,可通过引入二级共价交联来控制所注射的水凝胶的生物物理性质,该二级共价交联被定制为在临床相关的时间尺度上进行。正在进行的工作包括体内水凝胶降解的检查,以及针对特定生物医学应用的实施。

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