Continuous Assessment of Carotid Diameter using an Accelerometer Patch Probe for Ambulatory Arterial Stiffness Monitoring

摘要

We present a system with an accelerometer patch probe design for non-invasive evaluation of carotid arterial stiffness. The proposed system could continuously measure the acceleration signal derived due to the propagation of blood pulse wave through the left carotid artery, double integrating and scaling it to estimate the accelerometer-derived carotid wall displacement. This functional principle was proved by comparing the accelerometer-derived carotid wall displacement with the carotid distension signal from the reference system ARTSENS? (ARTerial Stiffness Evaluation for Noninvasive Screening device) for all the recruited human subjects. Assuming the relationship to be linear, a one-time subject-specific calibration was performed with the simultaneously acquired reference distension signal and the accelerometer-derived carotid displacement signals on its anachrotic limbs data points (at systolic phases) for each subject. This calibration equation was tested with latterly acquired accelerometer signals and results in the measurement of accelerometer-derived carotid distension and lumen-diameter values. The ability of the accelerometer system to measure real-time carotid distension and lumen diameter in a repeatable beat-by-beat manner for arterial stiffness index evaluation was validated in-vivo. The accuracy of the obtained results was studied with our clinically validated reference system. The experimental validation study results exhibit the feasibility of using the developed accelerometer system for continuous carotid distension and lumen diameter measurements, whereby the estimation of carotid arterial stiffness.