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Linear Time-Varying Model Characterizes Invasive EEG Signals Generated from Complex Epileptic Networks

机译:线性时变模型表征了复杂癫痫网络生成的侵入性EEG信号

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Electrocorticography (ECoG) and stereotactic electroencephalography (SEEG) are popular tools for studying neural mechanisms governing behavior and neural disorders, such as epilepsy. In particular, clinicians are interested in identifying brain regions that start seizures, i.e., the epileptogenic zone (EZ) from such invasive recordings. Currently, they visually inspect signals from each electrode to locate abnormal activity, and are not informed by predictive models that can characterize such recordings and potentially increase accuracy in localizing the EZ. In this paper, we test whether a simple linear time varying (LTV) model is sufficient to characterize both ECoG and SEEG activity. Specifically, we construct linear time invariant models in consecutive time windows before, during and after seizure events creating an LTV model from data collected in one ECoG and one SEEG patient. We find that these LTV models accurately reconstruct both ECoG and SEEG time series measured suggesting that these LTV models can be used for EZ localization.
机译:电凝(ECOG)和立体定向脑电图(SEEG)是研究治疗治疗行为和神经疾病的神经机制的流行工具,例如癫痫。特别是,临床医生对识别开始癫痫发作的大脑区域,即癫痫术区(EZ)免受这种侵入性记录。目前,他们在视觉上检查来自每个电极的信号以定位异常活动,并且不通过可测量的模型来告知,可以表征这些录音,并且可能提高了本地化EZ的准确性。在本文中,我们测试了一个简单的线性时间变化(LTV)模型是否足以表征ECOG和Seeg活动。具体而言,我们在抓取事件之前,期间和之后在连续时间窗口中构建线性时间不变模型,从一个ECOG和一个eCG患者收集的数据创建LTV模型。我们发现,这些LTV模型精确地重建了ECOG和SEEG时间序列的测量,表明这些LTV型号可用于EZ本地化。

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