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Prostate whole-mount histology reconstruction and registration to MRI for correlating in-vivo observations with biological findings

机译:前列腺全部安装组织学中学重建和注册MRI,用于与生物学发现相关的体内观察

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Multi-parametric magnetic resonance imaging (mMRI) is the standard exam for prostate cancer diagnosis, staging and risk assessment in current clinical routine. Correlating mMRI in-vivo observations with biological findings from radical prostatectomy specimen would improve the optimal therapy selection. Thus, we proposed a method for reconstructing and registering the prostate whole-mount histology (WMH) to the MRI, considering a thin slicing of the prostatectomy specimen. The method was evaluated on 3 patients, included in a prospective study, for which hematein-eosinsafran and immunohistochemistry stainings were performed. The registration error was assessed by measuring the Euclidean distance between landmarks, previously identified by an expert on both mMRI and histological slices. The mean error was 4:90α1:34 mm. Our method demonstrated promising results for registering prostate WMH to in-vivo mMRI, thus allowing for spatial accurate correlation between radiologic observations and biological information.
机译:多参数磁共振成像(MMRI)是目前临床常规中前列腺癌诊断,分期和风险评估的标准考试。将MMRI与自由基前列腺切除术标本的生物学发现相关的MMRI in-Vivo观察将改善最佳治疗选择。因此,考虑到前列腺切除术样品的薄切片,我们提出了一种重建和登记前列腺全部安装组织学(WMH)的方法。该方法评估了3名患者,包括在前瞻性研究中,对其进行血液素 - 嗜胞嘧啶和免疫组织化学染色。通过测量地标之间的欧几里德距离来评估登记误差,以前由MMRI和组织学切片上专家识别的地标。平均误差为4:90α1:34 mm。我们的方法证明了将前列腺WMH注册到体内MMRI的有希望的结果,从而允许放射学观察和生物信息之间的空间准确相关性。

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